Publications

Wang, X., Brandão H.B., Le, T.B., Laub, M.T., Rudner, D.Z. (2017) Bacillus subtilis SMC complexes juxtapose chromosome arms as they travel from origin to terminus. Science 03 Feb 2017: Vol. 355, Issue 6324, pp. 524-527. (pdf) (supplement) (perspective)

Fenton, A.K., Mortaji, L.E., Lau, D.T., Rudner, D.Z., Bernhardt, T.G. (2016) CozE is a member of the MreCD complex that directs cell elongation in Streptococcus pneumoniae. Nat Microbiol. 2016 Dec 12;2:16237. (pdf) (supplement)

Rodrigues, C.D., Henry, X., Neumann, E., Kurauskas, V., Bellard, L., Fichou, Y., Schanda, P., Schoehn, G., Rudner, D.Z., Morlot, C. (2016) A ring-shaped conduit connects the mother cell and forespore during sporulation in Bacillus subtilis. Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11585-11590. (pdf) (supplement)

Meeske, A.J., Riley, E.P., Robins, W.P., Uehara, T., Mekalanos, J.J., Kahne, D., Walker, S., Kruse, A.C., Bernhardt, T.G., Rudner, D.Z. (2016) SEDS proteins are a widespread family of bacterial cell wall polymerases. Nature. 2016 Sep 29;537(7622):634-638. (pdf) (highlight) (highlight)

Rodrigues, C.D., Ramírez-Guadiana, F.H., Meeske, A.J., Wang, X., Rudner, D.Z. (2016) GerM is required to assemble the basal platform of the SpoIIIA-SpoIIQ transenvelope complex during sporulation in Bacillus subtilis. Mol Microbiol. 2016 Oct;102(2):260-273. (pdf) (supplement)

Meeske, A.J., Rodrigues, C.D., Brady, J., Lim, H.C., Bernhardt, T.G., Rudner, D.Z. (2016) High-Throughput Genetic Screens Identify a Large and Diverse Collection of New Sporulation Genes in Bacillus subtilis. PLoS Biol. 14(1): e1002341. (pdf) (supplement)

Widderich, N., Rodrigues, C.D., Commichau, F.M., Fischer, K.E., Ramirez-Guadiana, F.H., Rudner, D.Z., Bremer, E. (2016) Salt-sensitivity of σH and Spo0A prevents sporulation of Bacillus subtilis at high osmolarity avoiding death during cellular differentiation. Mol Micro. 100(1):108-24. (pdf) (supplement)

Arrieta-Ortiz, M.L., Hafemeister, C., Batem A,R, Chu, T., Greenfield, A., Shuster, B., Barry, S.M., Gallitto, M., Liu, B., Kacmarczy, T., Santoriello, F., Chen, J. Rodrigues, C.D., Sato, T., Rudner, D.Z., Driks, A., Bonneau, R., Eichenberger, P. (2015) An experimentally supported model of the Bacillus subtilis global transcriptional regulatory network. Mol Sys. Bio. 11: 839. (pdf)

Wang, X., Le, T.B., Lajoie, B.R., Dekker, J., Laub, M.T., Rudner, D.Z. (2015) Condensin promotes the juxtaposition of DNA flanking its loading site in Bacillus subtilis. Genes Dev. 29(15):1661-1675. (pdf) (supplement) (news and views)

Meeske, A.J., Sham, L.T., Kimsey, H., Koo, B.M., Gross, C.A., Bernhardt, T.G., Rudner, D.Z. (2015) MurJ and a novel lipid II flippase are required for cell wall biogenesis in Bacillus subtilis. Proc Natl Acad Sci U S A. 112(20):6437-6442. (pdf) (supplement) (highlight)

Wang, X., Rudner, D.Z. (2014) Spatial organization of bacterial chromosomes. Curr Opin Microbiol. 22, 66-72. Review. (pdf)

Wang, X., Montero Llopis, P., Rudner, D.Z. (2014) Bacillus subtilis chromosome organization oscillates between two distinct patterns. Proc Natl Acad Sci U S A. 111 (35) 12877-12882. (pdf) (commentary)

Lebar, M.D., May, J.M., Meeske, A.J., Leiman, S.A., Lupoli, T.J., Tsukamoto, H., Losick, R., Rudner, D.Z., Walker, S., Kahne, D. (2014) Reconstitution of Peptidoglycan Cross-Linking Leads to Improved Fluorescent Probes of Cell Wall Synthesis. J Am Chem Soc. 136(31):10874-7. (pdf) (supplement)

Broedersz, C.P., Wang, X., Meir, Y., Loparo, J.J., Rudner, D.Z., Wingreen, N.S. (2014) Condensation and localization of the partitioning protein ParB on the bacterial chromosome. Proc Natl Acad Sci U S A. 111 (24), 8809-14. (pdf) (supplement)

Graham, T.G., Wang, X., Song, D., Etson, C.M., van Oijen, A.M., Rudner, D.Z., Loparo, J.J. (2014) ParB spreading requires DNA bridging. Genes Dev. 28(11), 1228-38. (pdf) (supplement) (cover) (perspective)

Wang, X., Tang, O.W., Riley, E.P., Rudner, D.Z. (2014) The SMC condensin complex is required for origin segregation in Bacillus subtilis. Curr Biol. 24(3), 287-92. (pdf) (supplement) (dispatch)

Mastny, M., Heuck, A., Kurzbauer, R., Heiduk, A., Boisguerin, P., Volkmer, R., Ehrmann, M., Rodrigues, C.D., Rudner, D.Z., Clausen, T. (2013) CtpB assembles a gated protease tunnel regulating cell-cell signaling during spore formation in Bacillus subtilis. Cell. 155, 647-58. (pdf) (supplement)

Meisner, J., Montero Llopis, P., Sham, L.T., Garner, E., Bernhardt, T.G., Rudner, D.Z. (2013) FtsEX is required for CwlO peptidoglycan hydrolase activity during cell wall elongation in Bacillus subtilis. Mol Microbiol. 89,1069-83. (pdf) (supplement)

Rodrigues, C.D., Marquis, K.A., Meisner, J., Rudner, D.Z. (2013) Peptidoglycan hydrolysis is required for assembly and activity of the transenvelope secretion complex during sporulation in Bacillus subtilis. Mol Microbiol. 89, 1039-52. (pdf) (supplement) (dispatch)

Wang, X., Montero Llopis, P., Rudner, D.Z. (2013) Organization and segregation of bacterial chromosomes. Nat Rev Genet. 14, 191-203. Review. (pdf) (cover)

Doan, T., Coleman, J., Marquis, K.A., Meeske, A.J., Burton, B.M., Karatekin, E., Rudner, D.Z. (2013) FisB mediates membrane fission during sporulation in Bacillus subtilis. Genes Dev. 27, 322-34. (pdf) (supplement) (dispatch)

Yardimci, H., Wang, X., Loveland, A.B., Tappin, I., Rudner, D.Z., Hurwitz, J., van Oijen, A.M., Walter, J.C. (2012) Bypass of a protein barrier by a replicative DNA helicase. Nature. 492, 205-9. (pdf) (supplement)

Jackson, D., Wang, X., Rudner, D.Z. (2012) Spatio-temporal organization of replication in bacteria and eukaryotes (nucleoids and nuclei). Cold Spring Harb Perspect Biol. 4, a010389. (pdf)

Wagner-Herman, J.K., Bernard, R., Dunne, R., Bisson-Filho, A.W., Kumar, K., Nguyen, T., Mulcahy, L., Koullias, J., Gueiros-Filho, F.J., Rudner, D.Z. (2012) RefZ facilitates the switch from medial to polar division during spore formation in Bacillus subtilis. J Bacteriol. 194, 4608-18. (pdf) (supplement)

Garner, E.C., Bernard, R., Wang, W., Zhuang, X., Rudner, D.Z., Mitchison, T. (2011) Coupled, circumferential motions of the cell wall synthesis machinery and MreB filaments in B. subtilis. Science. 333, 222-5. (pdf) (supplement)

Bernard, R., Marquis, K.A., Rudner, D.Z. (2010) Nucleoid occlusion prevents cell division during replication fork arrest in Bacillus subtilis Mol. Micro. 78, 866-82. (pdf) (supplement)

Morlot, C., Uehara, T., Marquis, K.A., Bernhardt, T.G., Rudner, D.Z. (2010) A highly coordinated cell wall degradation machine governs spore morphogenesis in Bacillus subtilis Genes Dev 24:411-422. (pdf) (supplement) (cover)

Rudner, D.Z., Losick, R. (2009) Protein subcellular localization in bacteria. Shapiro and Losick (eds), CSHL press. (pdf)

Wagner, J.K., Marquis, K.A., Rudner, D.Z. (2009) SirA enforces diploidy by inhibiting the replication initiator DnaA during spore formation in Bacillus subtilis Mol. Micro. 73, 963-74. (pdf) (supplement)

Doan, T., Morlot, C., Meisner, J., Serrano, M, Henriques, A.O., Moran, C.P., Rudner, D.Z. (2009) Novel secretion apparatus maintains spore integrity and developmental gene expression in Bacillus subtilis PLoS Genetics 5. (pdf) (supplement)

Sullivan, N.L., Marquis, K.A., Rudner, D.Z. (2009) Recruitment of SMC to the origin by ParB-parS organizes the origin and promotes efficient chromosome segregation Cell 137, 697-707. (pdf) (supplement) (cover) (highlight)

Marquis, K.A., Burton, B.M., Nollmann, M., Ptacin, J.L., Bustamante, C., Ben-Yehuda, S., Rudner, D.Z. (2008) SpoIIIE strips proteins off the DNA during chromosome translocation Genes Dev 22:1786-1795. (pdf) (supplement) (cover) (highlight)

Campo, N., Marquis, K.A., Rudner, D.Z. (2008) SpoIIQ anchors membrane proteins on both sides of the sporulation septum in Bacillus subtilis JBC 283, 4975-82. (pdf) (supplement)

Rudner, D.Z. and Doan T., (2008) Intercompartmental signal transduction during sporulation in Bacillus subtilis Book Chapter in Chemical Communication among Bacteria. Winans and Bassler (eds), ASM press (pdf)

Burton, B.M., Marquis, K.A., Sullivan, N.L., Rapoport, T.A., Rudner, D. Z. (2007) The ATPase SpoIIIE transports DNA across fused septal membranes during sporulation in Bacillus subtilis Cell 131, 1301-12. (pdf) (supplement) (highlight)

Campo, N., Rudner, D.Z. (2007) SpoIVB and CtpB are both forespore signals in the activation of the sporulation transcription factor σK in Bacillus subtilis J. Bacteriol. 189, 6021-7. (pdf) (supplement)

Doan, T., Rudner, D.Z. (2007) Perturbations to engulfment trigger a degradative response that prevents cell-cell signaling during sporulation in Bacillus subtilis Mol. Micro. 64, 500-11 (pdf) (supplement)

Straight, P.D., Fischbach, M.A., Walsh, C.T., Rudner, D.Z., Kolter, R. (2007) A singular enzymatic megacomplex from Bacillus subtilis Proc. Natl. Acad. Sci. 104, 305-10. (pdf)

Tiyanont, P., Doan, T., Lazarus, M.B., Fang, X., Rudner, D.Z., Walker, S. (2006) Imaging peptidoglycan biosynthesis in Bacillus subtilis with fluorescent antibiotics. Proc. Natl. Acad. Sci. 103, 11033-8. (pdf)

Campo, N. and Rudner, D.Z. (2006) A branched pathway governing the activation of a developmental transcription factor by Regulated Intramembrane Proteolysis. Mol. Cell 23, 23-35. (pdf) (supplement)

Ben-Yehuda, S., Fujita, M., Liu, X.S., Gorbatyuk, B., Skoko, D., Yan, J., Eichenberger, P., Rudner, D.Z., Marko, J.F., Liu, J., Losick, R. (2005) Defining a centromere-like element in Bacillus subtilis by identifying the binding sites for the chromosome-anchoring protein RacA. Mol Cell 17, 773-82. (pdf)

Doan, T., Marquis, K. A., Rudner, D.Z. (2005) Subcellular localization of a sporulation membrane protein is achieved through a network of interactions along and across the septum. Mol. Micro 55, 1767-81. (pdf) (supplement)

Eichenberger, P., Fujita, M., Jensen, S. T., Conlon, E. M., Rudner, D.Z., Wang, S., Ferguson, C., Sato, T., Liu, J., Losick, R. (2004) The entire program of gene expression for a single differentiating cell type and its regulation by a linked series of feed-forward loops. PLoS Biol. 2, e328. (pdf)

Ben-Yehuda, S., Rudner, D.Z., and Losick R. (2003) Assembly of the SpoIIIE DNA translocase depends on chromosome trapping in Bacillus subtilis. Cur. Biol. 13, 2196-200. (pdf)

Pan, Q., Losick, R., and Rudner, D.Z. (2003) A second PDZ-containing serine protease contributes to the activation of the sporulation transcription factor σK in Bacillus subtilis. J. Bacteriol. 185, 6051-6. (pdf)

Ben-Yehuda, S., Rudner, D.Z., and Losick, R. (2003) RacA, a bacterial protein that anchors chromosomes to the cell poles. Science 299, 532-6. (pdf)

Rudner, D.Z., Pan, Q., and Losick, R. (2002) Evidence that subcellular localization of a bacterial membrane protein is achieved by diffusion and capture. Proc. Natl. Acad. Sci. 99, 8701-6. (pdf)

Rudner, D.Z. and Losick, R. A (2002) Sporulation membrane protein tethers the pro-σK processing enzyme to its inhibitor and dictates its subcellular localization. Genes Dev. 16, 1007-18. (pdf)

Rudner, D.Z. and Losick, R. (2001) Morphological coupling in development: lessons from prokaryotes. Dev. Cell 1, 733-42. (pdf)

Rudner, D.Z., Fawcett, P., Losick, R (1999) A family of membrane-embedded metalloproteases involved in regulated proteolysis of membrane-associated transcription factors. Proc. Natl. Acad. Sci. 96, 14765-70. (pdf)

Cline, T.W., Rudner, D.Z., Barbash, D.A., Bell, M., Vutien, R. (1999) Functioning of the Drosophila integral U1/U2 protein Snf independent of U1 and U2 small nuclear ribonucleoprotein particles is revealed by snf+ gene dose effects. Proc. Natl. Acad. Sci. 96, 14451-8.

Rudner, D.Z., Breger, K.S., Rio, D.C. (1998) Molecular genetic analysis of the heterodimeric splicing factor U2AF: the RS domain on either the large or small Drosophila subunit is dispensable in vivo. Genes Dev. 12, 1010-21.

Rudner, D.Z., Breger, K.S., Kanaar, R., Adams, M.A., Rio, D.C. (1998) RNA binding activity of heterodimeric splicing factor U2AF: at least one RS domain is required for high-affinity binding. Mol. Cell. Biol. 18, 4004-11.

Rudner, D.Z., Kanaar, R., Breger, K.S., Rio, D.C. (1998) Interaction between subunits of heterodimeric splicing factor U2AF is essential in vivo. Mol. Cell. Biol. 18, 1765-73.

Hamond, L., Rudner, D.Z., Kanaar, R., Rio, D.C. (1997) Mutations in the hrp48 gene, which encodes a Drosophila heterogeneous nuclear ribonucleoprotein particle protein, cause lethality and developmental defects and affect P-element third-intron splicing in vivo. Mol. Cell. Biol. 17, 7260-7267.

Lee, A.L., Volkman, B.F., Robertson, S.A., Rudner, D.Z., Barbash, D.A., Cline, T.W., Kanaar, R., Rio, D.C., Wemmer, D.E. (1997) Chemical shift mapping of the RNA-binding interface of the multiple-RBD protein Sex-lethal. Biochemistry 36, 14306-14317.

Adams, M.D., Rudner, D.Z., Rio, D.C. (1996) Biochemistry and regulation of pre-mRNA splicing. Curr. Opin. Cell Biol. 8, 331-339.

Rudner, D.Z., Kanaar, R., Breger, K.S., Rio, D.C. (1996) Mutations in the small subunit of the Drosophila U2AF splicing factor cause lethality and developmental defects. Proc. Natl. Acad. Sci. 93, 10333-10337.

Kanaar, R., Lee, A.L., Rudner, D.Z., Wemmer, D.E., Rio, D.C. (1995) Interaction of the Sex-lethal RNA binding domains with RNA. EMBO J. 14, 4530-4539.

Ireton, K., Rudner, D.Z., Siranosian, K.J., Grossman, A.D. (1993) Integration of multiple developmental signals in Bacillus subtilis through the Spo0A transcription factor. Genes Dev. 7, 283-294. (pdf)

Lowell, J.E., Rudner, D.Z., Sachs, A.B. (1992) 3’-UTR-dependent deadenylation by the yeast poly(A) nuclease. Genes Dev. 6, 2088-2099.

Rudner, D.Z., LeDeaux, J.R., Ireton, K., Grossman, A.D. (1991) The spo0K locus of Bacillus subtilis is homologous to the oligopeptide permease locus and is required for sporulation and competence. J. Bacteriol. 173, 1388-1398. (pdf)

Rudner, D.Z. and McDuffie, M. (1988) Period refinement for AP Canum Venaticorum. American Association of Variable Star Observers 17-19. (pdf)